→ December 26, 2012
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The Mold in Dr. Florey’s Coat and Proust Was a Neuroscientist.

I have a piece up today for Insiders on the Joel Hanrahan trade. There is no Klawchat this week due to the holidays.

If I asked you who invented penicillin, you’d probably give the standard answer of Alexander Fleming, and maybe recall a story of him accidentally getting some bread mold in a Petri dish and noticing its antibacterial qualities. Fleming, a Scottish bacteriologist, ended up sharing a Nobel Prize for this discovery and received accolades for decades beyond his death, even though, as Eric Lax details in the surprisingly gripping The Mold in Dr. Florey’s Coat: The Story of the Penicillin Miracle, Fleming wasn’t actually the first to identify that the Penicillium notatum mold could kill several dangerous species of bacteria, nor was he at all involved in the massive effort to translate this laboratory accident into a usable weapon for human medicine.

Lax’s work is brief (263 pages) and very easy to read, but his research into the subject of the discovery and development of the now-ubiquitous drug is thorough and relied heavily on first-person accounts from the era, including journal notes, correspondence, and interviews with surviving members of the team at Oxford that undertook years of experiments to figure out how to scale mold production and also understand its functioning. Fleming did share the Nobel with the Australian Howard Florey and the German-born Ernst Chain, but the latter two, working at the Dunn School of Pathology under the privations of wartime England, managed to demonstrate that P. notatum was safe to use in humans and effective against bacteria, including Streptococcus and Staphylococcus, that at that time had no known chemotherapeutic antagonists. (That is, if you got a staph infection from a scratch from a rose thorn, there wasn’t much hope for your recovery.) Fleming wasn’t even the first to notice that P. notatum had antibacterial properties – the Belgian bacteriologist Andre Gratia apparently observed it three years earlier, but, like Fleming, didn’t follow through.

Lax attempts to shine light on those who deserve it, not just Florey and Chain but others, including Norman Heatley, without whose knowhow the drug might never have been produced in quantity. Lax goes back to the myth of Fleming’s discovery of the mold’s effects – Fleming did indeed discover it, but the legend of how he did so, which he himself propagated once Florey’s team made the drug viable, is likely false, according to Lax’s research. The focus then shifts to the Dunn School and the difficulties Florey had in assembling a team, finding funding for their work, and in producing enough of the stuff to keep the testing going – even salvaging penicillin from the urine of patients fortunate enough to receive it, as more than half of what a patient was given was eventually excreted via the kidneys. Lax’s access to contemporary documents and later in-person accounts allows him to flesh out the personalities of these central actors, as well as providing details on some of the early successes and failures of the drug as the scientists figured out how best to use it, including the now-common practice of administering an antibiotic for a week or more past the disappearance of symptoms. I’ll also leave the very amusing detail of how pencillin extraction moved from P. notatum to the more potent P. chrysogenum to those of you who choose to read the book.

Where Lax could have gone further was in explaining the science behind penicillin’s action, which he mentions just briefly near the end of the book. Penicillin is a beta-lactam antibiotic that inhibits cell wall development in bacteria, especially Gram-positive ones – meaning that when one cell tries to divide, its cell wall will rupture rather than expanding and closing around each resulting cell, so no new cell is formed and the original cell becomes a wall-less and very fragile spheroplast. Resistance to penicillin also only earns scant mention, again at the very end of the book, with some polite hand-waving about the subject and positive words about penicillin’s continued effectiveness against Streptococcus, but no mention of the rise of Staphylococcus bacteria that have evolved resistance to beta-lactam antibiotics in general. This is a history of science book that leans more toward history yet is a little light on the science for my tastes, but that may increase its accessibility to less science-inclined readers and absolutely made it an easier book to tackle.

If you like your popular science books a little heavier on the science, I also just read Jonah Lehrer’s first book, Proust Was a Neuroscientist ($5.98 through that link), which draws parallels between various famous practicioners of the fine arts (and one very famous chef) and later discoveries, mostly by neurologists, that showed that the artists’ insights into human psychology and behavior were biologically justified. Lehrer’s star was nearly extinguished when the first chapter of his 2012 book Imagine – a book I enjoyed tremendously – was found to contain fabricated quotes from Bob Dylan, after which the publisher pulled the book from publication entirely rather than edit and re-release it. (It’s still a great book if you want to learn more about how to be more creative, especially in the workplace.) Proust Was a Neuroscientist is more like a collection of nonfiction stories that share a basic narrative structure: Lehrer introduces a famous writer, musician, or artist, describes his/her oeuvre and a particular advance or insight for which s/he is known, then explains the science behind that insight, discovered decades after the artist’s work.

My favorite chapter was, of course, the one on chef and culinary writer Auguste Escoffier, one of the fathers of modern French cuisine and the man who first wrote down a specific method – not just a recipe, but a concept – for making brown veal stock, now the foundation for an entire family of sauces without which French cuisine as we know it would not exist. Escoffier’s great contribution, according to Lehrer, was his understanding of what we now know as umami, the so-called “fifth taste” – the intensity of flavor produced by glutamate, which is recognized by the tongue and is found in rich foods from Parmiggiano-Reggiano to anchovies to soy sauce to cured meats to mushrooms. (It’s also found in powdered form as monosodium glutamate.) The chemical basis behind Escoffier’s insight was first discovered after he had already risen to prominence in European food circles and wasn’t fully demonstrated until long after his death. Lehrer uses these eight examples to plead for greater interaction between the science and art worlds, arguing that each can learn from the other if they speak a common, “third” language. That message is largely lost on me as someone who works in neither sphere, but some of the anecdotes, including the ones on Paul Cézanne and Igor Stravinsky, were fascinating reads because they involved areas of the fine arts in which I have little to no background, even as a casual fan. I don’t take a jaundiced view of Lehrer’s earlier work just because of the debacle around Imagine, so just as I still recommend that book with the caveats around its veracity, I recommend Proust Was a Neuroscientist as well even if its underlying message isn’t as powerful.

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→ November 30, 2012
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The Orchid Thief.

Susan Orlean’s 1998 book The Orchid Thief: A True Story of Beauty and Obsession showed up in Allison Hoover Bartlett’s The Man Who Loved Books Too Much as one of that author’s favorite narrative non-fiction works, so I grabbed a used copy as soon as I came across one. “Narrative” is only loosely applicable to Orlean’s work, which violates one of my main rules on non-fiction works – unless the author is the subject, the author shouldn’t appear in the book much, if at all – but The Orchid Thief mostly succeeds in spite of Orlean’s heavy presence on the pages because her twin subjects, orchids and the wackadoos who collect them obsessively, are so fascinating. The book was adapted, loosely, by Charlie Kaufman for his script for Adaptation., which is more about Kaufman’s difficulty adapting the book for the big screen than it is about the story in the book itself.

The thief of the book’s title is John Laroche, who was arrested in 1994 while working for the Seminole Nation in Florida as a horticulturalist who wanted to build a nursery and lab that could clone rare orchids, creating a sustainable revenue source for the tribe while feeding Laroche’s own mad obsession with the flowers. Laroche hoped to exploit a loophole in federal laws on taking endangered plants from federally-protected lands by employing Seminole tribe members to take these rare orchids from lands technically under the Seminole Nation’s control, a legal inconsistency that opens up into an ethical quandary over adminstration of lands under Native American control, which Orlean unfortunately chooses not to address. Instead, she follows the crazy people in the orchid world, each one more eccentric than the last, while also explaining the botany of orchids and why people from so many walks of life become so obsessed with them.

Laroche has much in common with Bartlett’s own anti-hero, the book thief John Gilkey, between the psychology behind his madness and his ability to rationalize actions that are immoral and often illegal. Laroche isn’t quite the unrepentant thief that Gilkey is, as the latter merely deluded himself into believing that it was right for him to steal rare books because he couldn’t afford them, whereas Laroche had concocted a broader environmentalist rationalization that by exploiting the loophole, he’d force the government to close it, all while making money for the Seminole Nation and himself. Orlean describes Laroche as rakish and charming, even as good-looking, but on the printed page he comes off as erratic, self-centered, and exasperating. I couldn’t imagine being friends with this man, so it’s hard to see him as an object of desire for women – and there’s no evidence beyond Orlean’s own descriptions to indicate that he is one.

The strongest characters in The Orchid Thief aren’t the collectors or dealers, however, but the flowers themselves. Orchids – technically plants in the family Orchidaceae, which includes over 20,000 species and over 100,000 hybrids, according to Wikipedia – are tough to grow, requiring seven years from seed to bloom; bloom only for very short periods, as little as a single day per year; and depend on complicated relationships with other species to propagate, which has led, through natural selection, to unusual colors and shapes in the flowers designed to attract and/or trap birds or insects, allowing for the spread of an orchid’s pollen. Wild orchids also require the presence of specific fungi to provide sufficient carbon for the seeds to germinate properly, a symbiotic relationship that Orlean doesn’t mention in an otherwise lengthy discussion about just how rare orchids are. The orchids that Laroche wanted to steal grow in the forbidding Fakahatchee Strand State Preserve in Florida, a low-lying swampy expanse that is very difficult to access or navigate, but that forms the largest known home for the rare dendrophylax lindenii, also known as the ghost orchid, which Orlean becomes mildly obsessed with sighting in the wild while writing the book. (Orlean does provide an entertaining diversion on Florida land scams in the same area, where operators sold useless parcels of swampland to gullible cold-weather inhabitants.)

By the end of The Orchid Thief, the Seminole nation has fired Laroche and hired a less ambitious, more practical horticulturalist to run their nursery, while Laroche swears off orchids forever, leaving Orlean scrambling a little for a resolution to her book that doesn’t read like Acheron Hades just went into the original and erased the final dozen pages. The final chapter, which covers her trip into the Fakahatchee with a park ranger to try to spot a ghost orchid, would stand alone very well as a magazine feature, but its tenuous connection to the remainder of the book is a major reason why I wouldn’t call this a narrative work. It’s more of a broad study of interconnected stories around a single, compelling subject, one that touches on themes from morality to biology to beauty and madness, with a nonlinear and thus non-narrative structure that works because Orlean’s language is strong and clean.

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→ July 23, 2012
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The Golden Ratio.

Some recent ESPN links: Analyses of the Jays/Astros ten-player trade and the Brett Myers trade, as well as a big post on players I’ve scouted in the AZL over the last week, including Jorge Soler. The Conversation under the Myers piece has been rather bizarre, as a few (presumably male) readers are saying I shouldn’t have brought up Myers’ 2006 arrest on domestic violence charges. Needless to say, I think these complaints are spurious.

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I’m a big fan of mainstream books about mathematics, most of which would probably be best classified as “history of math” even if they’re discussing a currently unsolved problem, such as John Derbyshire’s excellent book on the Riemann Hypothesis, Prime Obsession. (And yes, I’m aware of Derbyshire’s political writing, but that doesn’t change the fact that the Riemann book is very well done.) Mario Livio’s book The Golden Ratio: The Story of φ, the World’s Most Astonishing Number was on my wish list for a long time because it seemed like a perfect blend of the academic and applied branches of mathematics, as the irrational number φ appears in numerous places in nature and (I thought) art. Unfortunately, Livio’s book spends more time talking about where φ is not than about where it is, making this more of a book of mythbusting than of math.

Livio does provide a solid introduction to φ, an irrational number equal to (1 + √5)/2 = 1.6180339887… that has several interesting properties, including:

* φ2 is equal to φ + 1, or 2.6180339887…
* 1/φ is equal to φ – 1, or 0.6180339887…
* If you take any line segment AB and place a point C on it such that the ratio of the longer half to the shorter half is equal to the ratio of the entire segment to the longer half, the ratio in question will be equal to φ
* The ratio between consecutive terms in the Fibonacci sequence – the series 0, 1, 1, 2, where each successive term is equal to the sum of the two terms before it, thus continuing with 3, 5, 8, 13, 21, ad infinitum – approaches φ. The ratio between the 17th and 16th terms is already 1.61800328…
* φ is also the result of the peculiar expression

The golden ratio also appears in many polygons and polyhedrons of interest not just to mathematicians but to artists, architects, and even botanists, as it appears in the spacing of leaves around the stems of many plants. But interest in the ratio has spurred no end of specious or outright fictitious claims about its appearance, including an oft-repeated one about its inclusion in the dimensions of the Parthenon (obtained by gaming the measurements to achieve the desired result) and another claiming Leonardo da Vinci used it in the Mona Lisa (similarly bogus). Livio devotes so much of the book to debunking these and other claims that by the time he gets around to discussing the golden ratio’s actual appearances in art, architecture, and nature, he’s devalued his subject by spending too little time explaining where φ is and too much time explaining where it ain’t.

Next up: I’m a bit behind here, having already finished Michael Ruhlman’s superb The Making of a Chef: Mastering Heat at the Culinary Institute of America, the book that first established him as one of the best writers on food and cooking today.

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→ March 31, 2012
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Saturday five, #2.

Five books, five links to my own stuff, and five links to others’ articles.

I’ve read eight books since my last post on any of them, so I’m going to take a shortcut and catch up by highlighting the five most interesting. Now that spring training is ending, I hope to get back to regular dishblogging soon.

* Charles Seife’s Zero: The Biography of a Dangerous Idea is the one non-fiction book in this bunch, a history-of-math tome that incorporates a fair amount of philosophy, physics, and religion all in a book that’s under 200 pages and incredibly readable for anyone who’s at least taken high school math. The subject is the number zero, long scorned by philosophers, theologians, and even some mathematicians who resisted the idea of nothing or the void, yet which turned out to be critical in a long list of major scientific advances, including calculus and quantum mechanics. I generally prefer narrative non-fiction, but Zero moves as easily as a math-oriented book can get without that central thread.

* Dashiell Hammett’s Nightmare Town is one of three major Hammett short-story collections in print (along with The Continental Op and the uneven The Big Knockover), and my favorite for its range of subjects and characters without feeling as pulpy as some of his most commercial stories. The twenty stories are all detective stories of one sort or another starring several different Hammett detectives, including early iterations of Sam Spade and the character who eventually became the Thin Man, as well as a western crime story that might be my favorite short piece by Hammett, “The Man Who Killed Dan Odams.”

* Readers have recommended Tim O’Brien’s short story cycle The Things They Carried for several years, usually any time I mention reading another book that deals with the Vietnam War and/or its aftermath. The book, a set of interconnected stories that feels like an novel despite the lack of a central plot, is based heavily on O’Brien’s own experiences in that conflict, especially around death – of platoon mates, of Viet Cong soldiers, of Vietnamese civilians, and of a childhood crush of O’Brien’s who died at age 9 of a brain tumor. The writing is remarkable, more than the stories themselves, which seemed to cover familiar ground in the genre, as well as O’Brien’s ability to weave all of these disconnected stories into one tapestry around that central theme of death and the pointlessness of war. The final story, where he ties much of it together by revisiting one of the first deaths he discussed in the book, is incredibly affecting on two levels as a result of everything that’s come before.

* I’m a big Haruki Murakami fan – and no, I haven’t read 1Q84 yet and won’t until it’s in paperback – but Dance, Dance, Dance was mostly a disappointment despite some superficial entertainment value, enough to at least make it a quick read if not an especially deep one. A sequel of sorts to A Wild Sheep Chase, it attempts to be more expansive than that earlier novel but still feels like unformed Murakami, another look at him as he built up to The Wind-Up Bird Chronicle, a top-ten novel for me that hit on every level. Dance is just too introspective, without enough of Murakami’s sort of magical realism (and little foundation for what magical realism it does contain) and no connection between the reader and the main character.

* I loved Edith Wharton’s The Age of Innocence, a funny, biting satire on upper-class life in the United States just after World War I, so I looked forward to House of Mirth, present on the Modern Library and Bloomsbury 100 lists, expecting more of that sharp wit but receiving, instead, a dry, depressing look at the limitations of life for women in those same social circles prior to the war. It’s a tragedy with an ironic title that follows Lily Bart through her fall from social grace, thanks mostly to the spiteful actions of other women in their closed New York society; it’s a protest novel, and one of the earliest feminist novels I’ve read (preceded, and perhaps inspired, by Kate Chopin’s The Awakening), but I found myself feeling more pity than empathy for Lily as a victim of circumstances, not of her own missteps.

Next up: I’m reading Martin Booth’s A Very Private Gentleman (filmed as The American) and listening to Jonah Lehrer’s Imagine: How Creativity Works. The Booth book is on sale through that link for $5.60.

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Five things I wrote or said this week:

On Jeff Samardzija’s revival.

This week’s chat.

One batch of spring training minor league notes, including the Angels, A’s, Rangers, and Royals.

Tuesday’s “top 10 players for 2017” column, which I emphasized was just for fun and still got people far too riled up. There’s no rational way to predict who the top ten players will be in five years and I won’t pretend I got them right. But it was fun to do.

I interviewed Top Chef winner and sports nut Richard Blais on the Tuesday Baseball Today podcast, in which he talked about what it was like to “choke” (his word) in the finals on his first season and then face the same situation in his second go-round. We also talked about why I should break my ten-year boycott of hot dogs.

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And the links…

* The best patent rejection ever, featuring Borat’s, er, swimsuit.

* A spotlight on Massachusetts’ outdated liquor laws. For a state that likes to pretend it’s all progressive, Massachusetts is about thirty years behind the times when it comes to alcohol, to say nothing of how the state’s wholesalers control the trade as tightly as the state liquor board does in Pennsylvania. The bill this editorial discusses would be a small start in breaking apart their oligopoly, but perhaps enough to start to crumble that wall.

* I admit it, I’m linking to Bleacher Report, but Dan Levy’s commentary on how Twitter has affected what a “scoop” means, especially to those of us in the business, is a must read. And there’s no slidshow involved.

* The Glendale mayor who drove the city into a nine-figure debt hole by spending government money to build facilities for private businesses – including the soon-to-be-ex-Phoenix Coyotes – won’t run for a sixth term, yet she’s receiving more accolades than criticism on the way out. Put it this way: Given its schools, safety, and public finances, we never considered Glendale for a second when looking to move out here.

* The “pink slime” controversy has led the manufacturer to suspend production at three of its four plants. That makes for a good headline, but are job losses really relevant to what should be a discussion of whether this is something people, especially schoolchildren, should be consuming? And now the controversy is moving on to carmine dye, derived from an acid extracted from cochineal beetles and used in Starbucks frappuccinos. If nothing else, I applaud the new emphasis on knowing exactly what we’re eating.

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→ August 24, 2011
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The Immortal Life of Henrietta Lacks.

I mentioned this on Twitter earlier, but The Wire: The Complete Series on DVD is just $73 today on amazon through that link. Disclaimer: I don’t own it, because I’m buying episodes to watch on my iPad (which will cost me more in the long run, actually).

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Rebecca Skloot’s The Immortal Life of Henrietta Lacks (currently just $8 in paperback on amazon) is, by far, the best nonfiction book I’ve read since The Ballad of the Whiskey Robber, weaving together a scientific breakthrough, a personal tragedy, and Skloot’s own difficult effort in gathering the information required to write the book into a single compelling narrative that succeeds despite the lack of a definitive resolution or even clear “good” and “bad” sides to the central conflict.

Henrietta Lacks was a poor African-American woman who died very young of cervical cancer in 1951, after receiving radiation treatments at Johns Hopkins that started too late to save her very aggressive form of the disease. A researcher at the school had been trying for some time to grow a long-lasting culture of human cells without success, but the sample he took from Lacks’ cancer turned out to be, as the book’s title implies, immortal, launching a scientific revolution that is partially responsible for many medical miracles we take for granted today – and a commercial revolution from the sale of these “HeLa” cells that has paid her descendents a grand total of zero dollars.

In 1951, there were no laws on medical privacy nor were there laws or even good guidelines on informing patients about what might happen to tissues or fluids collected from them during treatment; a doctor or hospital could use extra samples for research and the patient wouldn’t even know about it, let alone require compensation. A lengthy medical case decided in 1990, Moore v. Regents of the University of California, would later establish that the patient has no right to financial remuneration from such usage (unless, of course, he established those rights in advance, such as by patenting any unique genes*), but in Lacks’ era there were no such rules, nor even understanding that these biological samples could have substantial financial value. (The researcher in the Moore case, David Golde, comes off as particularly sleazy in Skloot’s retelling. He took his own life in 2004.)

*This part resonated a little more strongly with me, as my daughter and I do share a unique mutation that causes an inborn error of metabolism called 3MCC, in which the third step in the breakdown of the essential amino acid leucine produces the “wrong” waste product. (The disease isn’t unique, but our mutation had not been seen before. We’re special like that.) I’m largely asymptomatic beyond an inability to build muscle mass, but my daughter has been hospitalized once for a metabolic crisis and has now been a vegetarian for almost three years to avoid excessive protein intake. I’m still trying to get an answer from Children’s Hospital in Boston on their policies in this area.

What’s worse in this case, however, is that Lacks’ family – widower, siblings, and children – were completely unaware that her tissues had been taken, were being used in research, or had generated millions of dollars in value for others. The family, still poor, still mostly uneducated, and without health insurance, learned about HeLa in the 1970s, and it created a mixture of emotions ranging from fear to anger to wonder (including whether their mother could “feel” what was being done to these cells) that opens up windows on to racial inequalities, , medical ethics debates, and the conflict between public good and privacy rights.

Skloot herself worked on this book for nearly a decade, largely because the Lacks family, scarred by past media attention and con artists looking to latch on to their plight, resisted her efforts to interview them for the book. She eventually forged a strong friendship with Henrietta’s daughter Deborah, a fascinating woman whose emotional growth was probably stunted by losing her mother at such a young age yet who abounds with manic energy that drives her (and Skloot) forward on the research path. Deborah never seems to think of the compensation question, but simply wants to learn about her mother and about what has happened to her cells, perhaps to create a connection that was denied to her when her mother died.

The Lacks family gives the book the narrative structure it needs – the rise of HeLa cells from their origins to a major scientific breakthrough would make for a nice pamphlet, but doesn’t have the drama to drive a work of narrative non-fiction. Following the Lacks family’s struggles from losing Henrietta, from media coverage of the HeLa cells, and from their outrage at how their mother’s cells were used without consent, compensation, or even the correct name (she was often referred to as “Helen Lane” in medical journals), makes the book so powerful. The book requires no knowledge of science beyond a high school biology class, as Skloot provides sufficient explanation of cell structure and replication for anyone to follow along, and her presentation of the ethical issues involved is extremely balanced and surprisingly dispassionate for someone who became very close to the human subjects of her research. As easy as it is to react to the Lacks saga by arguing that her family should at least have been paid after the fact, Skloot points out through her story that it’s not even clear who would pay her (the oncologist who harvested the cells didn’t profit personally from them), and that many of the leaps made through the use of HeLa cells for testing, like Jonas Salk’s polio vaccine, relied in no small part on the easy availability of these cells. It’s as complicated as any good story should be, informative, emotionally involving without resorting to sentimentality, and gives you enough of both sides to make you angry and make you question your own outrage as you read.

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→ March 31, 2011
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Five Equations that Changed the World.

My predictions for 2011 went up yesterday. Podcast and chat on Thursday.

Somehow I forgot to review Michael Guillen’s Five Equations that Changed the World
, a very strong look at five equations and the scientists who developed them that’s explained with very little math at all. Guillen’s target is the lay reader, a term which, since I haven’t taken a physics class since 1990, would include me.

The five equations aren’t hard to guess – they are, in the order in which Guillen presents them, Newton’s Universal Law of Gravity, Daniel Bernoulli’s Law of Hydrodynamic Pressure, Faraday’s Law of Electromagnetic Induction, the Second Law of Thermodynamics (discovered by Rudolf Clausius), and, of course, E = mc2, courtesy of Albert Einstein. But rather than just give the reader the equations and their derivations, Guillen crafts a short story around each, with background on each scientist’s life before the discovery*, the process that led to the development of the equation, and a brief epilogue on some major event or subsequent discovery that hinged on the equation itself. (For example, Newton’s law led to the manned mission to the moon, while Einstein’s led, of course, to the atom bomb.)

* So, does a scientist discover an equation, develop it, or something else? He doesn’t invent it, certainly; these are, as far as we know, immutable laws of our universe. I thought about using “unearth” to describe this process, but it seems to mundane, especially for Clausius’ and Einstein’s contributions. I’m open to suggestions here.

Newton’s and Einstein’s stories are rather well-known, I think, so I would say the most interesting sections of the book were the three that those two bookended. Clausius’ story was probably the least familiar to me, as I probably couldn’t have named him if asked. And what made his story interesting was how many other discoveries or developments had to happen along the way for him to be able to articulate his equation – including the invention of the thermometer, the creation of the calorie as both a unit and as a theory for the source of energy, and the life’s work of Julius Robert Mayer, a Bavarian doctor who first expostulated that all the energy in the universe had to add up to the energy that existed at the universe’s start (that is, the First Law of Thermodynamics), only to find himself rejected and ostracized by both the scientific and religious establishments of the time.

The final section of the book, on how Einstein’s theory of relativity led to the development of nuclear weapons, is a bit poignant as Einstein lived to see the destruction and regretted his role in encouraging President Roosevelt to order the development of the bomb. (I would imagine Einstein realized, however, that since the Germans would have eventually developed it themselves, the Manhattan Project was as much as a defensive move as an offensive one, even though it became an offensive weapon when we figured it out first.) Slightly less interesting, to me at least, was the extent of the family squabbles in the section on Bernoulli, where a pattern of fathers becoming jealous of talented sons tended to repeat itself in a way that would probably land them on Maury Povich today.

If you like the sound of this book but want something mathier, check out my review of Prime Obsession, a book about the development of the Riemann Hypothesis, perhaps the leading unsolved problem in mathematics today.

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→ August 16, 2010
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Prime Obsession.

I admit it: I am not afraid of math.

And if you’re not afraid of math either – in this case, some fairly heavy math – you might enjoy Prime Obsession: Bernhard Riemann and the Greatest Unsolved Problem in Mathematics as much as I did. It’s a book about an obscure question in the field of number theory, one that remains unsolved after 150 years and probably has little to no practical application, but John Derbyshire manages to give the subject some real personality while doing his best to make it accessible to readers who haven’t taken a lot of advanced math classes or who, like me, are a good 13 years removed from their last one.

The subject of Prime Obsession is the Riemann Hypothesis, which states that the non-trivial zeros of Riemann’s zeta function are half part real. “Non-trivial zeros,” in this case at least, are complex numbers (a + bi, where i is the imaginary number defined as the square root of negative 1 and b is nonzero) that give the result of 0 when plugged into the zeta function. “Half part real” means that a in that complex number is equal to ½.

The zeta function is the crux of the matter, the sum of the following infinite series:

That is:

Riemann posed his hypothesis when studying the Prime Number Theorem, which states that for any random number N, the probability of N being prime (and thus the frequency of primes around N) is roughly equal to the reciprocal of the natural logarithm of N, that is, 1/ln(N). In his one paper on the subject, he hypothesized that the frequency of primes and the differences between the actual frequency and the predicted frequency in the Prime Number Theorem was connected to the zeros of this zeta function. He couldn’t prove it at the time, and even though David Hilbert declared it one of the great mathematical problems of the 20th century in 1900, one of a list that has seen all but two of its number* solved, and in 2000 the Riemann Hypothesis was named one of the Millennium Prize Problems by the Clay Mathematics Institude. Prove or disprove it and you’ll get a cool million bucks for your trouble.

As you might imagine, solving the problem isn’t easy; indeed, it stands unsolved more than a decade after Sir Andrew Wiles’ solution of the equally perplexing problem of Fermat’s Last Theorem, one that required the development of an entire new field of mathematics (topology) unknown to Fermat at the time that he wrote that he had a “truly marvelous proof” to the problem. (Current thought is that whatever proof he had was incomplete.) The difficulty of proving or disproving the Riemann Hypothesis has led many of the major figures in mathematics, particularly in number theory, to attempt to tackle all or part of the problem or to work on further theorems and conjectures that build on the assumption that the “RH” is true. (And it has at least held true so far for very large numbers, which is not a proof but is weak evidence in its favor.)

Derbyshire’s main difficulty, beyond the lack of a clear resolution to the story, is making the solution of a potentially useless mathematical conundrum interesting; Wiles’ proof of Fermat’s Last Theorem was momentous and newsworthy, but the practical applications have been nil – it’s merely interesting to people who like numbers. Proving the Riemann Hypothesis would likely have a similar lack of real-world effects, and the hypothesis itself is a lot harder to grasp than Fermat’s Last Theorem was; the latter problem had an incredibly complex solution, but the question itself was easy for anyone who’d taken algebra to understand. Derbyshire does a masterful job of walking through the history of the Riemann Hypothesis, from earlier work on prime numbers, including the PNT, through Riemann’s brief life and career in mathematics to the major developments in the 151 years since his seminal paper appeared.

The book alternates between chapters walking through the math and chapters on the history and personalities involved in the hypothesis’ history. Carl Friedrich Gauss has a starring role early, while G.H. Hardy, Leonhard Euler, J.E. Littlewood, Jacques Hadamard, and Hilbert appear at some length later on. Derbyshire sprinkles stories of their peculiarities, senses of humor, and non-mathematical interests to keep the text lighter while also highlighting the chance occurrences that made some of the progress on the proof possible and regularly pointing out the remarkable longevity of most of the major mathematicians he mentions.

His math writing, while clearly geared to a lay audience, still got fuzzy for me when he got deeper into the zeta function as he tried to map it to the complex plane. Derbyshire relies on these “visual” interpretations that don’t correspond to any sort of plane or graphs that I’ve seen elsewhere, and I felt it was the one time he presupposed some familiarity with higher math on the part of the reader. But to his credit, he relies largely on algebra and gives a brief (re-)introduction to differentiation and integration for the short periods where calculus is necessary to move the math story forward. He also hits many major touchstones that will unlock memories for those of you who took and enjoyed lots of math classes, from the Sieve of Eratosthenes to the amazing Euler’s Identity, the latter of which states that

And if you look at that formula and are amused, fascinated, or just generally intrigued, Prime Obsession is a book for you.

I also recommend a book about one of the mathematicians who makes a cameo appearance in Derbyshire’s book, The Man Who Loved Only Numbers: The Story of Paul Erdős and the Search for Mathematical Truth. Erdős was a Hungarian-born savant who lived most of his life out of a suitcase, traveling the world, arriving at the doors of mathematicians he knew and announcing that “my brain is open,” after which he’d settle in for a few days or weeks and embark with his host on a streak of problem-solving and paper-writing. He had his own peculiar vocabulary, consumed large quantities of caffeine and later amphetamines, and combined brilliance and prolificacy (that’s peak and longevity for you Hall of Fame watchers) to the point where other mathematicians are referred to by their “Erdős number,” where a person who co-authored a paper with Erdős has an Erdős number of one, while others are marked by how many papers you must go through to create the shortest possible chain back to Erdős.

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→ December 28, 2008
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The Riddle of the Compass.

Amir Aczel’s The Riddle of the Compass: The Invention that Changed the World isn’t as strong as his first two books, Fermat’s Last Theorem (a very math-heavy book but one that relies on the centuries-long efforts to solve that problem for narrative greed) and God’s Equation (a more accessible work about great “blunder” by Albert Einstein that turned out to be correct). Although the story within Compass is mildly interesting, the book – just 159 pages in paperback, including diagrams and a few blank pages between chapters – is so superficial that we get neither story nor an interesting character. In fact, the predominant character in the book probably never existed.

Aczel argues that the compass was, at the time it was invented, the most important invention since the wheel, and produces a reasonable case for the argument while splitting time between the western “invention” of the compass and the evidence for a much earlier invention in China, where the device was used in medicine and by magicians but seldom if ever used for navigation in a country that rarely took to the sea. He takes a detour into Italian history, including an interesting chapter on Amalfi (now known as a tourist mecca, but briefly a maritime power and a flourishing city-state) that is itself a digression from the early inquiry into the alleged inventor of the compass, Flavio Gioia. It seems likely that Gioia himself never existed, and while it’s amusing to see how a missing comma could lead to the creation of a historical personage, it’s not much of a basis for a book.

Aczel accentutates the problem by himself glossing over details that, even if tangential, would add color to the book. While bemoaning both the west’s dismissive and patronizing treatment of Chinese culture during for most of the last millennium and China’s refusal (under multiple regimes) to reveal many scientific and medical secrets, he mentions the very recent discovery that an herb that Chinese doctors have long used as a treatment for malaria has had promising results in tests in western studies. He never mentions the plant’s name (it’s a type of wormwood known by the Latin name Artemisia annua) and lets the matter drop after the one-paragraph teaser.

Next up: A little Wodehouse for the holidays, with a trip to Blandings Castle in Summer Lightning , available only in the compilation Life at Blandings.

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→ October 22, 2007
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Top 25 non-fiction books.

Since this is probably going to be my lone post of the week, I figured it should be a long one. I started out planning to offer a list of the ten best nonfiction books I’ve read, and then found I’d written down thirty titles. I trimmed a few and settled on twenty-five. I’ve omitted self-help/instruction books (like books on cooking) and stuck to more serious topics, although some are lightly treated.

25. Seabiscuit, by Laura Hillenbrand. Heard the movie was terrible, which is a shame because the book was great. It’s a classic underdog story – horse thought to be too small, jockey blind in one eye, trainer with unorthodox methods, and so on – with Seabiscuit’s rise punctuated by several high moments and an almost too-good-to-be-true shot at redemption when he gets one last chance to win the race that has always eluded him.

24. The Catholic Church: A Short History, by Hans Küng. I’ll admit that this book may have a narrow appeal, but I think it’s a solid read even for those with no direct interest in the Catholic Church. Küng is the Church’s greatest internal critic, a Catholic priest and theologian who underwent an excommunication proceeding for his teachings. He rejects or questions several doctrines of the mundane Church, pointing out that such concepts as papal infallibility and the celibacy requirement for clergy are man-made, not divinely granted. The Catholic Church serves as a summary of many of his major works to date within the context of a Catholic’s history of the Church itself, dating back to its early days as a small-c catholic church hewing much more closely to the teachings of Christ than the bloated and often corrupt bureaucracy we see today.

23. The Prize Game, by Donald Petrie. A bit short and a bit slow, The Prize Game still has a fascinating and improbable story at its core: Piracy was once a government-sanctioned business with clear rules of engagement. Captured ships were known as “prizes” and there were strict guidelines for how captured cargo and sailors were to be treated. This style of privateering was all but ended after 1815, although the book does go briefly into privateering during the U.S. Civil War. If you’ve read any Patrick O’Brian books or perhaps played the Sid Meier game Pirates!, this book’s right up your alley.

22. The Invention of Clouds, by Richard Hamblyn. Reviewed briefly here. Hamblyn tells an interesting story about the amateur meteorologist who came up with the system of nomenclature and descriptions for clouds that is still more or less in use today. The only hitch here is that there wasn’t a lot of drama in the book – not that Hamblyn should have made any up – so the book just sort of flows along without the tension that tends to drive successful history of science books forward. There are some interesting asides, and it’s amazing to think that there was a time when science presentations to the public resulted in packed houses.

21. Kitchen Confidential, by Anthony Bourdain. Hilarious and cutting and explosive in its revelations of kitchen culture, Kitchen Confidential will make you think twice when deciding where to eat when eating out. And I would hope that it would teach all of you to head in the other direction when you see a sign that says “Discount Sushi.”

20. Catch Me If You Can, by Frank Abagnale. The movie sucked, but the book was great, and it’ll make you wonder why the movie’s producers felt the need to alter anything given how outrageous Abagnale’s life of deception was. He pioneered a new type of check-kiting and is one of the greatest social engineers the world has ever seen – all because he wanted to impress the ladies. And if his tale is to be believed, impress them he did.

19. The Power of Babel, by John McWhorter. Reviewed in depth here, Power offers us a history of human languages with a good dose of McWhorter’s own opinions, including his view that language is a dynamic, living entity that can only be constrained through fiat. He also takes the view that all “languages” are merely dialects, and explains why some languages still have nasty features like noun declensions and the subjunctive mood while others have lost them over time.

18. The Island of Lost Maps, by Miles Harvey. The Island of Lost Maps tells the story of one of the boldest and for a time most successful thieves of whom you’ve never heard, a milquetoast man – appropriately named Bland – who cut antique maps out of rare books in university libraries and sell them to collectors. Bland made about a half-million dollars in the early 1990s before he was caught. Harvey weaves Bland’s story in with a few other narratives, including a description of the map-collecting industry, the history of this sort of maps, and his own obsession with the story and with learning about the map world. That last thread is the one major negative of Island, as I’m firmly in the camp that says that a nonfiction book’s author doesn’t belong in the book unless he’s the subject as well.

17. God’s Equation, by Amir Aczel. Aczel’s first book was Fermat’s Last Theorem, a history of that famous equation and the math that led up to the ultimate solution by Andrew Wiles. The book started with a riveting description of Wiles’ first presentation of his solution – I’m serious, you’ll be caught up in it too – but the rest of the book was dry and very mathy, with only the occasional bit of real-life drama (like the suicide of one of the Japanese mathematicians whose work was invaluable to Wiles) to keep it moving. For his second book, however, Aczel chose a broader topic and crafted a much stronger narrative, describing how Albert Einstein’s greatest “mistake,” that of the cosmological constant (a sort of high-physics fudge factor) turned out, in the end, to be correct.

16. The Lighthouse Stevensons, by Bella Bathurst. The family of Robert Louis Stevenson is known for something very non-literary: constructing a series of lighthouses around the dangerous coastlines of the British Isles. Not only were these projects dangerous and very difficult, they also disenfranchised the various communities of wreckers who thrived on the proceeds of shipwrecks off their shores, often killing survivors to ensure their hauls. (Bathurst, also a journalist and the author of one novel, started to lose her hearing a few years ago after a head trauma suffered in a car crash, and wrote a column on how the loss is not entirely without compensations.)

15. The Tummy Trilogy/Feeding a Yen, both by Calvin Trillin. A series of four books that are more collections of stories of the quest for good eats across America and eventually the world. The Tummy Trilogy’s stories are more folksy, while Feeding a Yen seemed more focused on the food, although the disappearance of Trillin’s wife Alice midway through that tome is a sad reminder of her early death in 2001.

14. All the President’s Men , by Bob Woodward and Carl Bernstein. Still riveting thirty-plus years later, the book is more about the reporters’ gradual uncovering of the Watergate scandal than it is about the scandal itself. Loses a bit of its romance now that we know who “Deep Throat” was.

13. Brunelleschi’s Dome, by Ross King. The story of the construction of the cupola on the duomo of Florence, Brunelleschi’s Dome focuses on the technological advances that Brunelleschi had to drive to be able to construct such a large dome without internal supports or risk of collapse. The story offers a surprising intensity because of the deadlines, the pressure from the Church, and various other external factors that make the project’s completion seem uncertain, although I can assure you from firsthand experience that it all worked out in the end. If you enjoyed this one, you might like the similar but fluffier Tilt, by Nicholas Shrady, about that crooked tower an hour down the A11 in Pisa.

12. Nathaniel’s Nutmeg, by Giles Milton. I picked this one up in the remainders room of a local independent bookstore for no other reason than the inclusion of my favorite spice in the book’s title. It turns out that it’s a riveting and thorough history of the Indonesian spice trade, which has not a little to do with the fact that we in the United States are speaking English today and not Dutch. Black pepper, mace (the aril covering the nutmeg seed itself), and cinnamon all make appearances, but nutmeg was the spice that drove the markets and led to fierce battles and even torture over the control of the Spice Islands, particularly the tiny nutmeg-producing island of Run.

11. Millionaire, by Janet Gleeson. I may be biased on this one, as the subject of Millionaire is the inventor of paper money, a manor-born English ne’er-do-well named John Law. Law’s financial genius (just sounds right, doesn’t it?) led to the development of modern currency systems and credit markets, but also created one of the biggest speculative booms and crashes in history, and led to the need for a new word to describe those who had amassed so much wealth: “millionaire.”

10. The Island at the Center of the World, by Russell Shorto. The story of the Dutch colony New Amsterdam, the early history of Manhattan (starting with the arrival of the Europeans, that is), and the enduring influence of the Dutch culture, language, and society on New York, both city and state, and the United States in general. Shorto had access to a recently-unearthed trove of over 12,000 pages of documents from the Dutch colonial government, and the result is a fascinating story with two heroes, the idealistic Adriaen van der Donck and the better-known but half-villian Peter Stuyvesant, some serious villains in the English, the Swedes’ short-lived foray into colonization, and early experiments in things like democracy, tolerance, and free trade.

9. Living to Tell the Tale, by Gabriel García Marquéz. I’m not big on memoirs, but this book has a lot of the feel of a Marquez novel, and if you’ve read One Hundred Years of Solitude, then Living to Tell the Tale will give you a lot of insight into where the amazing stories from that novel originated. He’s lived a fascinating life, and his role as a journalist in the midst of revolutions and strife provides some incredible and often darkly comic stories.

8. Lords of the Realm, by John Helyar. Still the best book about Major League Baseball I’ve ever read, although it’s somewhat out of date. Helyar looks at MLB as a business and delves into a lot of the self-dealing and corruption that have shaped the monolithic monopoly we see today. And indeed, the self-dealing hasn’t stopped since the book’s publication.

7. Freakonomics, by Steven Levitt and Stephen Dubner. The book responsible for the -onomics nomenclature scourge does do wonders to lift the image of the dismal science, showing how we can use data to learn things about human behavior and how we respond to changes in our economic world. Freakonomics includes a highly-controversial study of the connection between the legalization of abortion and the drop in crime in the 1990s, but also includes an interesting chapter on the life cycles of baby names, a chapter on why realtors – excuse me, Realtors® – are running a bit of a scam, and an ever more relevant chapter on cheating.

6. The Professor and the Madman/The Meaning of Everything, both by Simon Winchester. These two books, not strictly original/sequel but still inextricably linked, revolve around the production of the Oxford English Dictionary, a 70-year project that outlived all of its original heads and contributors. Professor is the better-known and more successful of the two books, telling the story of the asylum-bound murderer who proved to be one of the most prolific contributors of example sentences to the OED project, but I found it lacked the sort of narrative greed that propels Meaning, which tells the story of the OED’s history from genesis through publication, forward. I don’t see why you’d read one and not jump to read the other, though, since each offers a built-in teaser for its partner book.

5. Liar’s Poker, by Michael Lewis. I’ve got some serious issues with Moneyball, where Lewis put the narrative ahead of strict adherence to the facts, fabricating the anecdote that includes a mention of me towards the end of the book (and declining to correct it between the hardcover and paperback editions when I pointed out that it wasn’t true). As a result, I look at Liar’s Poker with a slightly jaundiced eye, because I’m not sure if the same accuracy problems infect Lewis’ other books. But I can’t deny that Lewis is a master of prose and storycraft, and Liar’s Poker is a cracking good read, with hilarious stories and comical characters and the intensity you’d expect to see in scenes set in a bond-trading room in the wild boom leading up to the 1987 crash.

4. Longitude, by Dava Sobel. I’ve always seen Longitude as the book that started the whole history-of-science book craze, by taking an esoteric story around a forgotten hero and crafting it as a novel, complete with villains, setbacks, and a linear plot that leads to a big climax. And as it turns out with so many of the best books in the genre, the invention at the heart of Longitude made the world as we know it possible: Transoceanic voyages were not safe until the invention of the chronometer, a device that allowed a ship in the middle of the ocean to determine its longitudinal location and thus its distance from Europe or the Americas. Longitude remains one of the kings in this field because the trials and tribulations faced by its hero, clockmaker John Harrison, were so severe.

3. Mauve, by Simon Garfield. The remarkable story of a teenaged chemist named William Perkin who in effect invented a color while trying to create a synthetic form of the anti-malarial compound quinine. Perkin’s mistake left him with a strong dye he called mauveine and an industrial process that would allow for easy, large-scale production. Perkin became a global celebrity, and his visit to the United States in 1906 was front-page news in the New York Times. He’s all but forgotten today outside of an award named after him that is given to a leading scientist in the field of applied chemistry.

2. Charlie Wilson’s War, by George Crile. Reviewed at length here, and soon to be a major feature film adapted by Aaron Sorkin and starring Tom Hanks. The book revolves around two amazing characters and their successful launching of the largest covert military operation in history, the U.S. funding and arming of the Afghan mujahideen, whose guerrilla warfare against Russian invaders was a major factor in the collapse of the Soviet Union.

1. Barbarians at the Gate, by Brian Burrough and John Helyar. Still, for my money, the most novelesque non-fiction book I’ve ever read. Helyar and Burrough couldn’t have created better characters if they tried. The superficial story here is the takeover battle for RJR Nabisco, but the real story is how some very wealthy and intelligent men managed to act like teenaged boys when winning became more important than maximizing profits. The leveraged buyout of RJR Nabisco, until 2007 the largest LBO in history, ended up costing the victors in the battle nearly 50% more per share than the original offer due to the bidding war between multiple suitors, with the primary players being a management-led group that includes Shearson-Lehman, the buyout firm Kohlberg Kravis Roberts, and rival buyout firm Forstman Little. One entertaining subplot is RJR’s then-failing effort to introduce a smokeless cigarette without admitting that cigarette smoke itself was a health hazard. Good luck with that.

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